2-Propanaminium, N,N,N-tris(1,1-dimethylethyl)-2-methyl-, fluoride → 3-((trans-4-hydroxy-2-(S)-pyrrolidinyl)methoxy)pyridine
반응식
Cl.Cl.[OH:3][C@H:4]1[CH2:8][NH:7][C@H:6]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=CN=2)[CH2:5]1.[F-].[C:18]([N+:22](C(C)(C)C)(C(C)(C)C)C(C)(C)C)(C)(C)C>C1COCC1>[OH:3][C@H:4]1[CH2:8][NH:7][C@H:6]([CH2:9][O:10][C:11]2[CH:18]=[N:22][CH:14]=[CH:15][CH:16]=2)[CH2:5]1참가 물질
4
실험 절차
A 1.35 g sample of the compound from step 72d above was dissolved in 9 mL of THF and 9.3 mL of tetra-(t-butyl)ammonium fluoride was added. The reaction mixture was stirred at room temperature for 16 hours, and the volatiles were removed under vacuum. The residue was purified on silica gel, eluting with 3:1 ethyl acetate:hexane, to give the title compound.
후처리
- customthe volatiles were removed under vacuum
- customThe residue was purified on silica gel
- washeluting with 3:1 ethyl acetate
출처 및 근거
- ORD 기록
- ord-78fc82dea4fe4ac29c88121716436574
- 출처 데이터셋
- uspto-grants-1999_06
- 특허 번호
- US05914328
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