Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1417142생성일: 2026년 10월 26일
Dicyclohexylcarbodiimide → N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester
https://huagongshe.com/reaction/1417142
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | Leucine, N-carboxy-, N-benzyl ester, L- | HCID 74840 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | N-[(Phenylmethoxy)carbonyl]-L-leucine 2,5-dioxo-1-pyrrolidinyl ester | HCID 11089751 | — |
반응 단계
Z-Leu-OH (15.92 g) and N-hydroxysuccinimide (6.9 g) were dissolved in dioxane and cooled to 0° C. To the cooled solution, DCC was added and stirred at 0° C. for 0.5 h, then room temp overnight. After filtering off the byproduct urea, the filtrate was concentrated to give crude Z-Leu-OSu as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05876945 |
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| 출처 데이터셋 | uspto-grants-1999_03 |
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| ORD ID | ord-da0ff85caf214165971ae330a7f8e1af |
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| 출처 메모 | uspto-grants-1999_03 |
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