Cyclohexylbenzene → 4-Cyclohexylbenzene-1-sulfonyl chloride

HRID 1417296

반응식

HRID 1417296 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][S:14](O)(=[O:16])=[O:15].[Cl-].[NH4+]>C(Cl)Cl>[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 13229CyclohexylbenzeneHCID 24638Chlorosulfonic acidHCID 25517Ammonium Chloride

생성물 1

HCID 43394424-Cyclohexylbenzene-1-sulfonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
5 °C

실험 절차

A solution of 10.6 ml of phenylcyclohexane in 100 ml of methylene chloride was added at 5° C. within 30 minutes to 13.8 ml of chlorosulfonic acid. The mixture was stirred at 5° C. for 1 hour, poured into 400 ml of a 20% ammonium chloride solution and extracted twice with 300 ml of methylene chloride each time. The organic phases were combined, dried with magnesium sulphate and the solvent was removed on a rotary evaporator. 13.6 g of 4-cyclohexyl-benzenesulfonyl chloride separated as a reddish oil, which was used without further purification.

후처리

  1. extractionextracted twice with 300 ml of methylene chloride each time
  2. dry with materialdried with magnesium sulphate
  3. customthe solvent was removed on a rotary evaporator
  4. custom13.6 g of 4-cyclohexyl-benzenesulfonyl chloride separated as a reddish oil, which
  5. customwas used without further purification

출처 및 근거

ORD 기록
ord-50e0745eb0ae4b8cb298c4bbbb30b492
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877193

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