Hydrazine → HCID 54501591, 화합물

HRID 1417315노트

반응식

HRID 1417315 반응식
[N:1]1([C:6]2[CH:27]=[CH:26][C:9]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.NN>C(O)C>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[CH:26][CH:27]=2)[CH:5]=[N:4][N:3]=[N:2]1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 67598186HCID 67598186, 화합물

생성물 1

HCID 54501591HCID 54501591, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 19.4 g of 2-[4-[4-(1H-tetrazol-1-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione (Example 38) in 400 ml boiling ethanol is treated with 3 ml of anhydrous hydrazine, and the mixture stirred at reflux for 16 hours. The precipitate is collected, washed with 200 ml of hot 1.5N HCl, and 50 ml of H2O. The combined ethanol, hydrochloric acid, and water filtrates are taken to dryness in vacuo to give the hydrochloride salt of the title compound. A portion of the salt was recrystallized from hot ethanol, m.p. 197°-198° C. (dec.).

후처리

  1. temperatureat reflux for 16 hours
  2. customThe precipitate is collected
  3. washwashed with 200 ml of hot 1.5N HCl, and 50 ml of H2O

출처 및 근거

ORD 기록
ord-be7bda1fb04847e8bc6a9ba5b9f71bbd
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877196

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