Dipropylamine → 2-(Dipropylamino)isonicotinonitrile

반응식

Cl[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][N:9]=1)[C:5]#[N:6].[CH2:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:11][CH3:12]>>[CH2:10]([N:13]([CH2:14][CH2:15][CH3:16])[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][N:9]=1)[C:5]#[N:6])[CH2:11][CH3:12]

참가 물질

반응물 2

HCID 8902Dipropylamine

HCID 5686382-Chloro-4-cyanopyridine

생성물 1

HCID 146408542-(Dipropylamino)isonicotinonitrile

반응 조건

온도: 100 °C

실험 절차

2-Chloroisonicotinonitrile (1.0 g) and dipropylamine (10 mL) were placed in a sealed heavy wall tube and heated to 100° C. for 18 h. The mixture was removed from heat and cooled to room temperature. The dipropylamine was removed under reduced pressure and the residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent to give 1.06 g of the title compound: MS (ESI+) for C12H17N3 m/z 204.1 (M+H)+.

후처리

customThe mixture was removed
temperaturefrom heat
temperaturecooled to room temperature
customThe dipropylamine was removed under reduced pressure
customthe residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent

출처 및 근거

ORD 기록: ord-8806db662bf2457fa8f1fc0dac0d23e5
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07727997B2

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