홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

(6aR,7S,9aS,13aS)-5-benzyloxy-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-6a,7,10,10-tetramethyl-11-(1-oxa-4-azacyclohex-4-yl)imino-3-oxo-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindole → (6aR,7S,9aS,13aS)-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-5-hydroxy-6a,7,10,10-tetramethyl-11-(1-oxa-4-azacyclohex-4-yl)imino-3-oxo-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindole

HRID 1417629
노트
인쇄 미리보기

반응식

HRID 1417629 반응식
C([O:8][C:9]1[C:10]2[CH2:22][C@:21]3([CH3:41])[C@@H:23]([CH3:40])[CH2:24][CH2:25][C@H:26]4[C:27]([CH3:39])([CH3:38])[C:28](=[N:31][N:32]5[CH2:37][CH2:36][O:35][CH2:34][CH2:33]5)[CH2:29][CH2:30][C@@:20]34[O:19][C:11]=2[C:12]2[CH2:13][NH:14][C:15](=[O:18])[C:16]=2[CH:17]=1)C1C=CC=CC=1>CO.[C].[Pd]>[OH:8][C:9]1[C:10]2[CH2:22][C@:21]3([CH3:41])[C@@H:23]([CH3:40])[CH2:24][CH2:25][C@H:26]4[C:27]([CH3:39])([CH3:38])[C:28](=[N:31][N:32]5[CH2:33][CH2:34][O:35][CH2:36][CH2:37]5)[CH2:29][CH2:30][C@@:20]34[O:19][C:11]=2[C:12]2[CH2:13][NH:14][C:15](=[O:18])[C:16]=2[CH:17]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 86753836(6aR,7S,9aS,13aS)-5-benzyloxy-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-6a,7,10,10-tetramethyl-11-(1-oxa-4-azacyclohex-4-yl)imino-3-oxo-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindole

생성물 1

HCID 86753837(6aR,7S,9aS,13aS)-2,3,6,6a,7,8,9,9a,10,11,12,13-dodecahydro-5-hydroxy-6a,7,10,10-tetramethyl-11-(1-oxa-4-azacyclohex-4-yl)imino-3-oxo-1H-benzo[8,8a][1]benzopyrano[2,3-e]isoindole수율 81.3%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매
HCID 887
Methanol
용매

실험 절차

To a solution of Compound (61) (224 mg, 0.40 mmol) in 50 ml of methanol containing 1% water was added 180 mg of 10% palladium-carbon, followed by catalytic reduction. After the palladium-carbon was removed by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel 10 g; ethyl acetate:methanol=99:1) and further crystallization from diethyl ether-n-hexane to give 152 mg (79%) of Compound (51f).

후처리

  1. customAfter the palladium-carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by a silica gel column chromatography (silica gel 10 g; ethyl acetate:methanol=99:1) and further crystallization from diethyl ether-n-hexane

출처 및 근거

ORD 기록
ord-21aaaf18b81c44468575da1faed23197
출처 데이터셋
uspto-grants-1999_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05876984

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트