Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexahydro-1,4-diazepine → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzamide methanesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexahydro-1,4-diazepine | HCID 68163 | — |
| 반응물 | 4-Fluorobenzamide | HCID 71572 | — |
| 반응물 | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| 반응물 | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| 반응물 | (-)-2-(Isochroman-1-yl)ethanol | HCID 14141298 | — |
| 반응물 | 4-(Homopiperazin-1-yl)benzamide | HCID 28410931 | — |
| 반응물 | N-Methyl-(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide N-Methyl-4-fluorobenzenesulfonamide | HCID 86753846 | — |
| 생성물 | (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzamide methanesulfonate | HCID 86753847 | — |
반응 단계
Following the general procedure for EXAMPLE 49 and making non-critical variations (-)-2-(isochroman-1-yl)ethanol (LXXIX, 0.394 g) and 4-(homopiperazin-1-yl)benzamide (IV; 0.601 g prepared by the method of EXAMPLE 47, Step 1 from 4-fluorobenzamide, III, and homopiperazine, II) are combined to give the title compound, mp 163.75°-165°; MS (m/z) 379; [α]D -41° (c, 0.975, DMF); IR(mineral oil) 1609, 1043, 1662, 1167 and 1216 cm-1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05877317 |
| 출처 데이터셋 | uspto-grants-1999_03 |
| ORD ID | ord-e68cdfcc45d54cc0aa5e138216c234c0 |
| 출처 메모 | uspto-grants-1999_03 |