2-(4-Aminophenoxy)acetamide → HCID 70187532, 화합물

반응식

Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:16]([CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1)(=[O:18])[NH2:17]>>[C:16]([CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:2]2[CH:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:23][CH:22]=1)(=[O:18])[NH2:17]

참가 물질

반응물 2

HCID 30260062-(4-Aminophenoxy)acetamide

HCID 51046229HCID 51046229, 화합물

생성물 1

HCID 70187532HCID 70187532, 화합물수율 30%

실험 절차

Using an analogous procedure to that described in Example 13, 4-chloro-6-(3'-methylanilino)pyrimidine (0.23 g) was reacted with 4-(carbamoylmethoxy)aniline to give 4-[4'-(carbamoylmethoxy)anilino]6-(3'-methylanilino)pyrimidine in 30% yield, m.p. 212°-215° C.;

출처 및 근거

ORD 기록: ord-d47c389894e440869ef064115a3a2fa9
출처 데이터셋: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05880130

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