1-Propanol → HCID 131720992, 화합물

HRID 1418799노트

반응식

HRID 1418799 반응식
[O:1]=[C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH3:14])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].O.[C:16]1(C)[CH:21]=CC(S(O)(=O)=O)=C[CH:17]=1.C1(C)C=CC=CC=1.CCCO>O>[CH2:17]([O:4][C:3](=[O:5])[C:2]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH3:14])=[CH:8][CH:7]=1)=[O:1])[CH2:16][CH3:21]

참가 물질

6

반응물 4

HCID 10311-PropanolHCID 1140TolueneHCID 521998p-Toluenesulfonic acid monohydrateHCID 50548412-(4-Ethoxyphenyl)-2-oxoacetic acid

생성물 1

HCID 131720992HCID 131720992, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

10.4 g (50 mmol) of α-oxo-4-ethoxyphenylacetic acid (Bandyopahyay et al., J. Ind. Chem. Soc. 66(4), 239, 1989) and 1.0 g of p-toluenesulfonic acid-monohydrate are refluxed into a mixture of 100 ml of toluene and 50 ml of N-propanol while in a water separator until no more water separates out. Then, it is concentrated by evaporation in a vacuum, the residue is dispersed between ethyl acetate and sodium bicarbonate solution, the organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

후처리

  1. concentrationThen, it is concentrated by evaporation in a vacuum
  2. additionthe residue is dispersed between ethyl acetate and sodium bicarbonate solution
  3. customthe organic phase is dried on magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-4fb444f1d22d4e30bd56431180d64251
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05885548

반응 노트

불러오는 중…