N-benzyl-3-nitrobenzamide → 3-amino-N-benzylbenzamide

HRID 1418861노트

반응식

HRID 1418861 반응식
[C:1]1([CH2:7][NH:8][C:9](=[O:19])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[C:1]1([CH2:7][NH:8][C:9](=[O:19])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 347075N-benzyl-3-nitrobenzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 41998383-amino-N-benzylbenzamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A sample of the product of step (a), 8.8 g, was dissolved in 100 ml of methanol and hydrogenated with 0.4 g of 10% palladium on carbon and 50 PSI hydrogen. After 90 minutes, the mix was filtered and evaporated. The solid residue was slurried in ethyl ether, and filtered to provide crude N-phenylmethyl-3-aminobenzamide, mp 95°-100° C., m.s. (M+H)+ =227

후처리

  1. filtrationthe mix was filtered
  2. customevaporated
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-e9bd5ff733194f538fbc12d45fc0c142
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05885985

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