1-(3,4-Xylyl)piperazine → 6-[4-(4-Methylpyridin-2-yl)piperazin-1-ylmethyl]-1,2,3,4-tetrahydroquinoxaline

반응식

[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:3]=1.C[C:15]1[CH:16]=[C:17]([N:22]2CC[NH:25][CH2:24][CH2:23]2)[CH:18]=[CH:19][C:20]=1[CH3:21]>>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:21][C:20]3[CH:19]=[C:18]4[C:17](=[CH:16][CH:15]=3)[NH:22][CH2:23][CH2:24][NH:25]4)[CH2:10][CH2:9]2)[CH:3]=1

참가 물질

반응물 2

HCID 27237821-(3,4-Xylyl)piperazine

HCID 27600581-(4-Methylpyridin-2-yl)piperazine

생성물 1

HCID 98401976-[4-(4-Methylpyridin-2-yl)piperazin-1-ylmethyl]-1,2,3,4-tetrahydroquinoxaline

실험 절차

Example 10 was prepared according to Example 2 except that in Step A 1-(4-methylpyridin-2-yl)piperazine is substituted for 1-(3,4-dimethylphenyl)piperazine; mp 179°-180° C.

후처리

customExample 10 was prepared

출처 및 근거

ORD 기록: ord-b5574fd0162f4bb9af48257a1aae832e
출처 데이터셋: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05885994

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