Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 178418454, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | trans-7-Chloro-5-(2-chlorophenyl)-3-(3-cyanophenylaminocarbonylmethyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine | HCID 69946147 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178418454 | HCID 178418454 | 50.9% |
반응 단계
A solution of 0.2 g of trans-7-chloro-5-(2-chlorophenyl)-3-(3-cyanophenylaminocarbonylmethyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine and 80 mg of sodium azide in 5 ml of dimethylformamide was stirred at 90° C. for 60 hours. After water was added, the mixture was washed with water, after which the solvent was removed and the residue was subjected to silica gel column-chromatography to yield 0.11 g of a crystal.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05885979 |
| 출처 데이터셋 | uspto-grants-1999_03 |
| ORD ID | ord-f306cfa200ec46a6a1e0340bff629340 |
| 출처 메모 | uspto-grants-1999_03 |