Ammonia → 6-Cyano-1-(2-carbamoylvinyl)-2-naphthol

HRID 1419255노트

반응식

HRID 1419255 반응식
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([CH:14]=[CH:15][C:16](OCC)=[O:17])=[C:9]([OH:21])[CH:8]=[CH:7]2)#[N:3]>>[C:2]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([CH:14]=[CH:15][C:16](=[O:17])[NH2:1])=[C:9]([OH:21])[CH:8]=[CH:7]2)#[N:3]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 53697716HCID 53697716, 화합물

생성물 1

HCID 537790446-Cyano-1-(2-carbamoylvinyl)-2-naphthol

실험 절차

2.0 Liters of 25% aqueous ammonia was added to 25.2 g of 6-cyano-1-(2-ethoxycarbonylvinyl)-2-naphthol, followed by stirring at 40°-45° C. for 32 hours. After cooling, the reaction mixture was concentrated to 300 ml under reduced pressure, and the residue was stirred for 30 minutes under cooling with water. The precipitate was collected by filtration and washed with a small amount of water and acetone to obtain 9.55 g of the desired product.

후처리

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated to 300 ml under reduced pressure
  3. stirringthe residue was stirred for 30 minutes
  4. temperatureunder cooling with water
  5. filtrationThe precipitate was collected by filtration
  6. washwashed with a small amount of water and acetone

출처 및 근거

ORD 기록
ord-18b1e4c054544813a05ae764760e7d6d
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05885990

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