Carbon Dioxide → HCID 178516780, 화합물

HRID 1419483노트

반응식

HRID 1419483 반응식
NC[C:3]([C:5]1[N:6]=[CH:7][N:8]([C@@H:15]2[O:20][C@H:19]([CH2:21][OH:22])[C@@H:17]([OH:18])[C@H:16]2[F:23])[C:9]=1[N:10]=[CH:11][N:12](C)[CH3:13])=[O:4].C[O-].[Na+].C(=O)=O>CO>[F:23][C@@H:16]1[C@H:17]([OH:18])[C@@H:19]([CH2:21][OH:22])[O:20][C@H:15]1[N:8]1[C:9]2[N:10]=[CH:11][NH:12][CH2:13][C:3](=[O:4])[C:5]=2[N:6]=[CH:7]1

참가 물질

5

반응물 3

HCID 280Carbon DioxideHCID 10942334Sodium MethoxideHCID 537945224-aminoacetyl-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-5-(dimethylaminomethyleneamino)imidazole

생성물 1

HCID 178516780HCID 178516780, 화합물수율 36%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

The compound (24) (20 mg) obtained in item (13) above was dissolved in methanol (0.4 ml), to which was added a 0.2M sodium methylate solution (0.4 ml) in methanol and the resulting mixture was allowed to stand at room temperature overnight. The reaction solution obtained was neutralized with addition of dry ice, then concentrated to leave a residue and the residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1), affording the titled compound (25) (6.2 mg) as a colorless solid. Yield: 36%.

후처리

  1. customThe reaction solution obtained
  2. concentrationconcentrated
  3. customto leave a residue
  4. customthe residue was purified by silica gel column chromatography (developer; chloroform-methanol, 4:1)

출처 및 근거

ORD 기록
ord-9d6120a78bae44259dfc44240380669a
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05886167

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