Anisole → HCID 53953369, 화합물

HRID 1419492노트

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HRID 1419492 반응식
[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[C:12]1([O:18][CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)Cl>[CH3:19][O:18][C:12]1[CH:17]=[CH:16][C:15]([C:4]([C:3]2[C:2]([Cl:1])=[C:10]([CH3:11])[CH:9]=[CH:8][CH:7]=2)=[O:5])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 7519AnisoleHCID 193679402-Chloro-3-methylbenzoyl chloride

생성물 1

HCID 53953369HCID 53953369, 화합물수율 97%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

A solution of 2-chloro-3-methylbenzoyl chloride (18.05 mmol), [prepared as described above] in dry CH2Cl2 (60 ml) was cooled to 0° C. and AICl3 (2.41 g, 1 eq.) was added. After ten minutes, anisole (1.96 ml, 1 eq.) was added. The resulting orange colored reaction mixture was allowed to warm to room temperature, stirred for 3 h and then poured on ice. The product was extracted into ether, washed with brine, and dried over MgSO4 . The solvent was evaporated in vacuo to give 3-(4-methoxybenzoyl)-2-chlorotoluene (4.55 g, 97% yield) as a solid, mp 64.7°-65.8° C.

후처리

  1. additionAICl3 (2.41 g, 1 eq.) was added
  2. waitAfter ten minutes
  3. temperatureto warm to room temperature
  4. additionpoured on ice
  5. extractionThe product was extracted into ether
  6. washwashed with brine
  7. dry with materialdried over MgSO4
  8. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-a1b2805c9a9443f9b71e39b049c4ad63
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05886178

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