Iometopane → 3b-(4-Iodophenyl)tropane-2b-carboxylic

HRID 1419661노트

반응식

HRID 1419661 반응식
[C:1]([C@H:5]1[C@@H:11]([C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][CH:13]=2)[CH2:10][C@H:9]2[N:19]([CH3:20])[C@@H:6]1[CH2:7][CH2:8]2)([O:3]C)=[O:2]>O.O1CCOCC1>[C:1]([C@H:5]1[C@@H:11]([C:12]2[CH:13]=[CH:14][C:15]([I:18])=[CH:16][CH:17]=2)[CH2:10][C@H:9]2[N:19]([CH3:20])[C@@H:6]1[CH2:7][CH2:8]2)([OH:3])=[O:2]

참가 물질

3

반응물 1

HCID 108220Iometopane

생성물 1

HCID 156397973b-(4-Iodophenyl)tropane-2b-carboxylic

시약·촉매·용매 1

HCID 218864351,4-Dioxane--water (1/1)용매

실험 절차

A round bottom flask filled with a solution of 100 mg of 2β-Carbomethoxy-3β-(4-Iodophenyl)tropane in 10 mL of 1:1 water/dioxane was heated to a gentle reflux for two days. The solvent was then removed and the white residue was triturated with hot ethyl acetate twice. The remaining solid was dried under in vacuo to yield 90 mg of CIT-acid 7, (93%) as a white solid.

후처리

  1. temperaturewas heated to
  2. temperaturea gentle reflux for two days
  3. customThe solvent was then removed
  4. customthe white residue was triturated with hot ethyl acetate twice
  5. customThe remaining solid was dried under in vacuo
  6. customto yield 90 mg of CIT-acid 7, (93%) as a white solid

출처 및 근거

ORD 기록
ord-df1fc272bc504d0c9138a3f71a3f28ec
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05888475

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