Potassium Carbonate → HCID 178448114, 화합물

HRID 1419800노트

반응식

HRID 1419800 반응식
Cl[C:2]1[C:7]([Cl:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.[C:11]([CH:14]1[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]1)([CH3:13])=[CH2:12].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Cl:8][C:7]1[C:2]([NH:20][C@H:17]2[CH2:18][CH2:19][C@@H:14]([C:11]([CH3:13])=[CH2:12])[CH2:15][CH2:16]2)=[N:3][CH:4]=[N:5][C:6]=1[CH2:9][CH3:10]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 111376684,5-Dichloro-6-ethylpyrimidineHCID 540303434-Isopropenylcyclohexylamine

생성물 1

HCID 178448114HCID 178448114, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

1.6 g (0.009 mol) of 4,5-dichloro-6-ethylpyrimidine and 1.2 g (0.009 mol) of 4-isopropenylcyclohexylamine were stirred with 1.8 g (0.013 mol) of K2CO3 in 10 ml of DMF at 80° C. for 6 hours. After cooling to room temperature, the mixture was placed in water and extracted with ether. The organic phase was washed with water, dried and filtered, and the filtrate was chromatographed on silica gel with petroleum ether/ethyl acetate 7:3 in order to separate the cis/trans isomers.

후처리

  1. extractionextracted with ether
  2. washThe organic phase was washed with water
  3. customdried
  4. filtrationfiltered
  5. customthe filtrate was chromatographed on silica gel with petroleum ether/ethyl acetate 7:3 in order
  6. customto separate the cis/trans isomers

출처 및 근거

ORD 기록
ord-c05b3b2636594daea4524067c447dec8
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05889012

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