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Water → HCID 70047959, 화합물

HRID 1419908
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인쇄 미리보기

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HRID 1419908 반응식
Cl[CH2:2][CH:3]([OH:20])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:8][CH:7]=1.[CH3:21][C:22]1[CH:35]=[CH:34][C:25]([CH2:26][C:27]2([OH:33])[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:24][CH:23]=1.C(=O)([O-])[O-].[K+].[K+].O>CC(=O)CC>[CH2:13]([O:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]([OH:20])[CH2:2][N:30]2[CH2:31][CH2:32][C:27]([CH2:26][C:25]3[CH:24]=[CH:23][C:22]([CH3:21])=[CH:35][CH:34]=3)([OH:33])[CH2:28][CH2:29]2)=[CH:7][CH:8]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 105362424-(4-Methylbenzyl)-piperidin-4-olHCID 133384981-Chloro-3-[4-(phenylmethoxy)phenoxy]-2-propanol

생성물 1

HCID 70047959HCID 70047959, 화합물수율 48%

시약·촉매·용매 1

HCID 6569
Methyl Ethyl Ketone
용매

실험 절차

A mixture of (RS)-1-chloro-3-[4-(benzyloxy)phenoxy]-2-propanol (1.0 g, 3.4 mmol), 4-(4-methyl-benzyl)-piperidin-4-ol (0.70 g, 3.4 mmol) and potassium carbonate (0.50 g, 3.6 mmol) in 2-butanone was refluxed for 2 days. It was cooled to room temperature, 50 ml of H2O were added and the organic phase was separated. The water phase was extracted two times with ethyl acetate. The organic phases were then pooled, dried with Na2SO4 and the solvent evaporated. The residue was chromatographed over silica gel (CH2Cl2 --MeOH, 98:2) to give (RS)-1-[3-(4-benzyloxy-phenoxy)-2-hydroxy-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol as a colorless solid (0.75 g, 48%). MS: m/e=462.5 (M+H+)

후처리

  1. temperaturewas refluxed for 2 days
  2. customthe organic phase was separated
  3. extractionThe water phase was extracted two times with ethyl acetate
  4. dry with materialdried with Na2SO4
  5. customthe solvent evaporated
  6. customThe residue was chromatographed over silica gel (CH2Cl2 --MeOH, 98:2)

출처 및 근거

ORD 기록
ord-6c632db133ab4a2b9abe02815eadb83f
출처 데이터셋
uspto-grants-1999_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05889026

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