반응식
[CH3:1][C@@H:2]([O:9][C:10]([CH:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=2)[CH2:13]1)=[O:11])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].FC(F)(F)[C@H:25]([OH:32])CCCCCC.[CH2:35]([C:45]1[CH:50]=[CH:49][C:48]([C:51]2[CH:56]=[CH:55][C:54](C(O)=O)=[CH:53][CH:52]=2)=[CH:47][CH:46]=1)[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH3:1][C@@H:2]([O:9][C:10]([CH:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([O:22][C:25]([C:56]3[C:51]([C:48]4[CH:49]=[CH:50][C:45]([CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])=[CH:46][CH:47]=4)=[CH:52][CH:53]=[CH:54][CH:55]=3)=[O:32])[CH:18]=2)[CH2:13]1)=[O:11])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
To a mixture of 0.37 g (1.1 mmol) of 1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid (R)-1-methylheptyl ester obtained as in the fourth stage of Example 23 where (R)-1-methyl heputanol was used in stead of (R)-1-trifluoromethylheptanol, 0.33 g (1.1 mmol) of 4'-decylbiphenyl-4-carboxylic acid (FK-1124-10 from Teikoku Kagaku Sangyo K.K.), 0.013 g (0.11 mmol) of 4-N,N-dimethylaminopyridine and 10 ml of methylene chloride was added dropwise 5 ml of a methylene chloride solution containing 0.27 g (1.3 mmol) of N,N'-dicyclohexylcarbodiimide with stirring at room temperature over a period of 2.5 hours.
후처리
- customobtained as in the fourth stage of Example 23 where (R)-1-methyl heputanol
출처 및 근거
- ORD 기록
- ord-184fb5dc82c740e2b4c51bcf3ae69124
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05725798
연결된 노트
불러오는 중…