Potassium Carbonate → 9-Phenylnonan-2-one

HRID 1420527노트

반응식

HRID 1420527 반응식
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:14]([CH2:17]C(=O)C)(=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[C:8]1([CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:15][C:14](=[O:16])[CH3:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 145296726-Phenyl-1-hexyl iodide

생성물 1

HCID 187819999-Phenylnonan-2-one수율 54%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6-Iodo-1-phenylhexane (17.43 g, 0.061 mol), acetyl acetone(6.66 g, 0.067) and potassium carbonate (8.41 g, 0.061 mol) were dissolved in dry absolute ethanol (75 ml) nd the solution was retluxed for 18 hours. After cooling to room temperature the solution was filtered and evaporated under reduced pressure to an oil. This was partitioned between ethyl acetate (80 ml) and water (80 ml), and the organic layer was washed with brine, dried and evaporated to an orange oil (15.27 g). This was purified by flash chromatography on silica gel using petroleum ether/ethyl acetate to give 9-phenylnonan-2-one as a colourless oil (7.12 g, 54%).

후처리

  1. filtrationwas filtered
  2. customevaporated under reduced pressure to an oil
  3. customThis was partitioned between ethyl acetate (80 ml) and water (80 ml)
  4. washthe organic layer was washed with brine
  5. customdried
  6. customevaporated to an orange oil (15.27 g)
  7. customThis was purified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-80084a365440440e94850acbfdf238ce
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071899

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