Methanol → Sulindac Sulfide Methyl Ester

HRID 1420720노트

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HRID 1420720 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([OH:24])=[O:23].S(Cl)(Cl)=O.[CH3:29]O>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([O:24][CH3:29])=[O:23]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 5352624Sulindac Sulfide

생성물 1

HCID 16046334Sulindac Sulfide Methyl Ester

실험 절차

To a suspension of (Z)-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid (51 g, 0.15 mol) in methanol (600 mL) at 0° C. there was slowly added thionyl chloride (26.8 g, 0.225 mol). The mixture was then stirred at room temperature for 2 hours and filtered to afford the title compound as a yellow solid, mp 73-75° C.

후처리

  1. filtrationfiltered

출처 및 근거

ORD 기록
ord-55a10ff20b5b48ae9ef5fd2dcb3395ac
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071934

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