4-Chloropyridinium chloride → HCID 11243907, 화합물

HRID 1420769노트

반응식

HRID 1420769 반응식
CO[C:3]1(OC)[CH2:7][CH2:6][CH2:5]O1.[Cl-].ClC1C=C[NH+]=CC=1.[NH2:18][C:19]1[C:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30][CH3:31])=[CH:22][S:21][C:20]=1[C:32]([O:34][CH3:35])=[O:33]>O1CCOCC1>[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:23]1[C:19]([N:18]2[CH:3]=[CH:7][CH:6]=[CH:5]2)=[C:20]([C:32]([O:34][CH3:35])=[O:33])[S:21][CH:22]=1

참가 물질

5

반응물 3

HCID 108772904-Chloropyridinium chlorideHCID 11311579HCID 11311579, 화합물HCID 11788317Dimethoxytetrahydrofurane

생성물 1

HCID 11243907HCID 11243907, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5.2 mmol of dimethoxytetrahydrofuran and 5.2 mmol of 4-chloropyridinium chloride in 100 ml of dioxane are stirred for 15 minutes at ambient temperature and then 5.2 mmol of the compound obtained in Step C are added. The reaction mixture is then heated at reflux of the solvent for 3 hours and subsequently filtered. After concentrating the filtrate under reduced pressure, the residue obtained is crystallised by trituration in ethyl ether, allowing the expected product to be isolated.

후처리

  1. temperatureThe reaction mixture is then heated
  2. temperatureat reflux of the solvent for 3 hours
  3. filtrationsubsequently filtered
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue obtained
  6. customis crystallised by trituration in ethyl ether
  7. customto be isolated

출처 및 근거

ORD 기록
ord-26cb5e0cfa7247b680d4ed77986e50ee
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071945

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