Nitromethane → HCID 9927343, 화합물

HRID 1420772노트

반응식

HRID 1420772 반응식
Br[C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1.[OH-].[K+].[N+:24](C)([O-:26])=[O:25]>>[N+:24]([C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1)([O-:26])=[O:25]

참가 물질

4

반응물 3

HCID 6375NitromethaneHCID 14797Potassium HydroxideHCID 9906877HCID 9906877, 화합물

생성물 1

HCID 9927343HCID 9927343, 화합물

실험 절차

A solution of 1 mmol of the compound obtained in Example 12 in 50 ml of nitromethane is stirred for 12 hours at ambient temperature and the reaction mixture is then poured into a 1M potassium hydroxide solution. After extracting with dichloromethane, the organic phases are dried over sodium sulphate, filtered and concentrated under reduced pressure. Chromatography on silica gel (chloroform) allows the expected product to be isolated.

후처리

  1. extractionAfter extracting with dichloromethane
  2. dry with materialthe organic phases are dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customto be isolated

출처 및 근거

ORD 기록
ord-725fbe83ab464311998c3e82eca88d25
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071945

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