HCID 9906877, 화합물 → HCID 9818192, 화합물

HRID 1420773노트

반응식

HRID 1420773 반응식
Br[C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1.[CH3:22][O-:23].[Na+]>>[CH3:22][O:23][C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1

참가 물질

3

반응물 2

HCID 9906877HCID 9906877, 화합물HCID 10942334Sodium Methoxide

생성물 1

HCID 9818192HCID 9818192, 화합물

실험 절차

1 equivalent of the compound obtained in Example 12 is stirred, at ambient temperature, into a solution of sodium methanolate. After 12 hours' reaction, the reaction mixture is concentrated under reduced pressure. The residue is taken up in dichloromethane; the organic phase is then washed with a saturated NaCl solution, dried over sodium sulphate and then concentrated under reduced pressure. Chromatography on silica gel (dichloromethane) allows the expected product to be isolated.

후처리

  1. customAfter 12 hours' reaction
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. washthe organic phase is then washed with a saturated NaCl solution
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated under reduced pressure
  6. customto be isolated

출처 및 근거

ORD 기록
ord-7cd672cc323f4c6685717e511b5d3afb
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071945

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