Dichloromethane → 2-Bromophenylmethylsulfoxide
반응식
[OH:1]OS([O-])=O.[K+].[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14][CH3:15].C(=O)(O)[O-].[Na+].ClCCl>O.CC(C)=O>[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([CH3:15])=[O:1]참가 물질
7
실험 절차
Oxone (9.7 g) in water (40 ml) was added slowly to a stirred, cooled cooled (0° C.) solution of 2-bromothioanisole (5 g, 24.6 mmol) and sodium bicarbonate (16 g) in acetone (20 ml). The mixture was stirred for at room temperature 16 h., then water and dichloromethane was added. The layers were separated and the organic phase was dried (MgSO4) and the solvent was evaporated under reduced pressure. The residue was purified by chromatography on silica gel, eluting with hexane/EtOAc (80:20 increasing to 40:60) to give the title compound (6.1 g). m/z (ES+) 219 (M+1).
후처리
- temperaturecooled
- customThe layers were separated
- dry with materialthe organic phase was dried (MgSO4)
- customthe solvent was evaporated under reduced pressure
- customThe residue was purified by chromatography on silica gel
- washeluting with hexane/EtOAc (80:20 increasing to 40:60)
출처 및 근거
- ORD 기록
- ord-05da3fab12bc48b6b6030ec94b6d3426
- 출처 데이터셋
- uspto-grants-2000_06
- 특허 번호
- US06071927
반응 노트
불러오는 중…