Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Avermectin → Ivermectin CRS
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Avermectin | HCID 6858006 | — |
| 반응물 | Tris-(octylphenyl)-phosphine | HCID 22561076 | — |
| 생성물 | Ivermectin CRS | HCID 9812710 | — |
반응 단계
4.3 g of avermectin (B1a and B1b mixture) are, after addition of 53.2 mg of tris-(octylphenyl)-phosphine, hydrogenated using the conditions given in Example 1 (B). After a hydrogenation time of 7 hours, a crude ivermectin product is obtained which, according to HPLC analysis, contains 1.3% of avermectin, 94.8% of ivermectin and 2% of tetrahydroavermectin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06072052 |
| 출처 데이터셋 | uspto-grants-2000_06 |
| ORD ID | ord-ec79b6c038e94f30b0a3c8bf2cfedba0 |
| 출처 메모 | uspto-grants-2000_06 |