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Ammonia → 3-(1-methyl-3-indolyl)-4-(4-pyridyl)-1H-pyrrole-2,5-dione

HRID 1421184
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인쇄 미리보기

반응식

HRID 1421184 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:23])O[C:14](=[O:22])[C:15]=2[C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[CH:3]1.C[N:25](C=O)C.N>O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:23])[NH:25][C:14](=[O:22])[C:15]=2[C:16]2[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=2)=[CH:3]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 6228DimethylformamideHCID 187802473-(1-Methyl-3-indolyl)-4-(4-pyridyl)furan-2,5-dione

생성물 1

HCID 187802743-(1-methyl-3-indolyl)-4-(4-pyridyl)-1H-pyrrole-2,5-dione

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
140 °C

실험 절차

200 mg of 3-(1-methyl-3-indolyl)-4-(4-pyridyl)furan-2,5-dione were treated with 5 ml of DMF and 5 ml of 33% aqueous ammonia. The resulting solution was heated at 140° C. for 17 hours. After cooling, the suspension was diluted with water. The product was filtered off, washed with water and dried to give 144 mg of 3-(1-methyl-3-indolyl)-4-(4-pyridyl)-1H-pyrrole-2,5-dione, m.p. 332°-334° C.

후처리

  1. temperatureAfter cooling
  2. filtrationThe product was filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-bc7bf9e421254f168562f45ce5fd372f
출처 데이터셋
uspto-grants-2000_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
USRE036736

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