Methanol → Maribavir

HRID 1421480노트

반응식

HRID 1421480 반응식
[Cl:1][C:2]1[C:32]([Cl:33])=[CH:31][C:5]2[N:6]([C@H:13]3[O:25][C@@H:24]([CH2:26][O:27]C(=O)C)[C@H:19]([O:20]C(=O)C)[C@@H:14]3[O:15]C(=O)C)[C:7]([NH:9][CH:10]([CH3:12])[CH3:11])=[N:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].O.CO>C(O)C>[Cl:1][C:2]1[C:32]([Cl:33])=[CH:31][C:5]2[N:6]([C@H:13]3[O:25][C@@H:24]([CH2:26][OH:27])[C@H:19]([OH:20])[C@@H:14]3[OH:15])[C:7]([NH:9][CH:10]([CH3:11])[CH3:12])=[N:8][C:4]=2[CH:3]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 962WaterHCID 10340Sodium CarbonateHCID 53780792HCID 53780792, 화합물

생성물 1

HCID 471161Maribavir수율 84%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5,6-Dichloro-2-(isopropylamino)-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole (7.50 g, 14.93 mmol), sodium carbonate (1.72 g, 16.23 mmol), water (29 mL), methanol (100 mL) and ethanol (100 mL) were used according to general procedure III. The product was purified by silica gel chromatography using 55:45 dichloromethanelmethanol to afford 4.72 g (84%) of a white foam. Analytical data were consistent with the assigned structure.

후처리

  1. customThe product was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-50b746d9c2224bec924adf992107661f
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06077832

반응 노트

불러오는 중…