Water → 4-((methylthio)methyl)benzonitrile(WX192182)
반응식
C(#N)C.[C:4]([C:6]1[CH:13]=[CH:12][C:9]([CH2:10]Br)=[CH:8][CH:7]=1)#[N:5].[Na].[CH3:15][SH:16].O>C1(C)C=CC=CC=1>[CH3:15][S:16][CH2:10][C:9]1[CH:12]=[CH:13][C:6]([C:4]#[N:5])=[CH:7][CH:8]=1참가 물질
6
실험 절차
To an acetonitrile solution (500 ml) of 4-cyanobenzyl bromide (50 g), 15% methyl mercaptan sodium salt (120 ml) was added at a room temperature and heated for 6 hours with refluxing. After cooling to a room temperature, water (1 l) and toluene (1 l) was added thereto. The organic layer was separated and washed successively with an aqueous 2N sodium hydroxide solution sulfate. After distilling off the solvent, 4-methylmercaptomethylbenzonitrile (38 g) was obtained.
후처리
- temperatureheated for 6 hours
- temperaturewith refluxing
- customThe organic layer was separated
- washwashed successively with an aqueous 2N sodium hydroxide solution sulfate
- distillationAfter distilling off the solvent
출처 및 근거
- ORD 기록
- ord-4244a8160d83451cabf1a5ebea20c65c
- 출처 데이터셋
- uspto-grants-2000_06
- 특허 번호
- US06077866
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