Tetrahydrofuran → HCID 18779765, 화합물

HRID 1421758노트

반응식

HRID 1421758 반응식
ClC1C=CC(=O)N(C2C=CC(CC3N([CH2:20][C:21]4[CH:26]=[C:25]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)[C:24]([C:33]#[N:34])=[CH:23][CH:22]=4)C=NC=3)=CN=2)C=1.[Li+].[BH4-].C1C[O:41]CC1>>[OH:41][CH2:20][C:21]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:24]([C:33]#[N:34])=[CH:23][CH:22]=1

참가 물질

4

반응물 3

HCID 8028Tetrahydrofuran2회HCID 4148881Lithium borohydrideHCID 18779714HCID 18779714, 화합물

생성물 1

HCID 18779765HCID 18779765, 화합물

반응 조건

온도
70 °C

실험 절차

6-Cyano-biphenyl-3-carboxylic acid methyl ester from step 2 (1.4 g, 5.9 mmol) was dissolved in THF (24 ml). LiBH4 in THF (2 M, 5.9 ml, 11.8 mmol) was added. The reaction mixture was heated to 70° C. for 3 hours. The reaction mixture was quenched carefully with 3N HCl and then extracted with EtOAc (3×20 mL). The organic layers were combined, washed with brine, dried (MgSO4), filtered and concentrated to yield the desired product.

후처리

  1. customThe reaction mixture was quenched carefully with 3N HCl
  2. extractionextracted with EtOAc (3×20 mL)
  3. washwashed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fcd2af2ec02e4bf5b3aea99cfb3d5916
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06077853

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