4-(3-Azido-1-imidazol-1-yl-propyl)-benzonitrile → 4-(3-Amino-1-imidazol-1-yl-propyl)-benzonitrile

HRID 1421781노트

반응식

HRID 1421781 반응식
[N:1]([CH2:4][CH2:5][CH:6]([C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1)[N:7]1[CH:11]=[CH:10][N:9]=[CH:8]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH2:5][CH:6]([C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1)[N:7]1[CH:11]=[CH:10][N:9]=[CH:8]1

참가 물질

4

반응물 1

HCID 187797504-(3-Azido-1-imidazol-1-yl-propyl)-benzonitrile

생성물 1

HCID 187797234-(3-Amino-1-imidazol-1-yl-propyl)-benzonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The 4-(3-azido-1-imidazol-1-yl-propyl)-benzonitrile (490 mg, 1.9 mmol) was suspended in methanol (20 mL) and placed under argon. 10% Palladium on Carbon catalyst was carefully added under argon and the solution was evacuated under vacuum to bubbling and then purged with argon 3 times. The suspension was evacuated again and then a balloon filled with hydrogen was opened to the reaction. The reaction was left under hydrogen at room pressure for 16 hours. The reaction was evacuated again to bubbling and purged with argon. The catalyst was filtered off through a bed of celite under argon. The supernatant was concentrated in vacuo to give the desired product.

후처리

  1. customthe solution was evacuated under vacuum
  2. customto bubbling
  3. custompurged with argon 3 times
  4. customThe suspension was evacuated again
  5. additiona balloon filled with hydrogen
  6. customwas opened to the reaction
  7. customThe reaction was evacuated again
  8. customto bubbling
  9. custompurged with argon
  10. filtrationThe catalyst was filtered off through a bed of celite under argon
  11. concentrationThe supernatant was concentrated in vacuo

출처 및 근거

ORD 기록
ord-d8aef07b022d4139aae622c3c65481d4
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06077853

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