5-(Methoxymethyl)furan-2-carboxylic acid → HCID 18780016, 화합물

HRID 1421808

반응식

HRID 1421808 반응식
[CH3:1][O:2][CH2:3][C:4]1[O:8][C:7]([C:9]([OH:11])=[O:10])=[CH:6][CH:5]=1.[H][H]>C(OCC)(=O)C.[Rh]>[CH3:1][O:2][CH2:3][CH:4]1[O:8][CH:7]([C:9]([OH:11])=[O:10])[CH2:6][CH2:5]1

참가 물질

5

반응물 2

HCID 11252275-(Methoxymethyl)furan-2-carboxylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 18780016HCID 18780016, 화합물수율 102.5%

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 5-methoxymethylfuran-2-carboxylic acid (3.10 g) in ethyl acetate (40 ml) was hydrogenated over 5% rhodium on carbon (200 mg) until hydrogen uptake ceased. The catalyst was filtered off and washed with ethyl acetate. The combined filtrates were evaporated to give the title compound as a colourless oil (3.26 g); νmax (film) 1750 cm-1 ; δH (CDCl3) 1.75-2.1 (2H,m), 2.1-2.6(2H,m,), 3.45 (3H,s), 3.47 (1H,dd, J 3 and 10 Hz), 3.74 (1H,dd, J 4 and 10 Hz), 4.15-4.43 (1H,m) and 4.43-4.63 (1H,m).

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashed with ethyl acetate
  3. customThe combined filtrates were evaporated

출처 및 근거

ORD 기록
ord-b09031cb78464d7ab5d97e97d45aad98
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06077952

연결된 노트

불러오는 중…