Ethanol → HCID 385223, 화합물

HRID 1421871노트

반응식

HRID 1421871 반응식
OC[CH:3]([NH2:8])[CH:4]1[CH2:7][CH2:6][CH2:5]1.[NH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1.[CH2:18]([OH:20])C>C(N(CC)CC)C>[NH2:9][C:10]1[N:15]=[C:14]([NH:8][CH2:3][C:4]2([CH2:18][OH:20])[CH2:5][CH2:6][CH2:7]2)[CH:13]=[C:12]([Cl:17])[N:11]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 655222-Amino-4,6-dichloropyrimidineHCID 15458387HCID 15458387, 화합물

생성물 1

HCID 385223HCID 385223, 화합물수율 92.3%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A mixture of 1-hydroxymethyl-1-cyclobutylmethylamine (5.75 g, 0.05 mol), 2-amino-4,6-dichloropyrimidine (8.20 g, 0.05 mol), ethanol (200 ml) and triethylamine (20 ml) was refluxed for one day. The solvent was distilled away under reduced pressure. The residue was washed with water, dried and recrystallized from acetone to give colorless prism crystals (11.2 g, 92.3%), m.p. 192-194° C. (acetone).

후처리

  1. temperaturewas refluxed for one day
  2. distillationThe solvent was distilled away under reduced pressure
  3. washThe residue was washed with water
  4. customdried
  5. customrecrystallized from acetone

출처 및 근거

ORD 기록
ord-2da758854a624c0887b4f377db1896d1
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080750

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