Cyclohexene → HCID 385194, 화합물

HRID 1421877노트

반응식

HRID 1421877 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[C:4](Cl)[N:3]=1.C1CCCCC=1>[OH-].[Pd+2].[OH-].C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 2

HCID 8079CyclohexeneHCID 385223HCID 385223, 화합물

생성물 1

HCID 385194HCID 385194, 화합물

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

To 2-amino-6-chloro-4-[[(1-hydroxymethyl-1-cyclobutyl)methyl]amino]pyrimidine (1.46 g, 6.0 mmol) were added ethanol (40 ml), cyclohexene (15 ml) and palladium hydroxide (0.2 g) in a nitrogen stream, and the mixture was refluxed for 2 hours. The reaction mixture was filtered and the solvent in the filtrate was distilled away under reduced pressure to give white amorphous crystals (1.34 g, quantitative).

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. filtrationThe reaction mixture was filtered
  3. distillationthe solvent in the filtrate was distilled away under reduced pressure
  4. customto give white amorphous crystals (1.34 g, quantitative)

출처 및 근거

ORD 기록
ord-239085a746b040f697a4476dde4d800f
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080750

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