Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl chloroformate → HCID 178526847, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 2-Bromo-5-nitrothiazole | HCID 18211 | — |
| 반응물 | 3-Amino-1-(2-(trifluoromethyl)phenyl)thiourea | HCID 723187 | — |
| 반응물 | 2-(Trifluoromethyl)phenyl isothiocyanate | HCID 737162 | — |
| 반응물 | HCID 178518949 | HCID 178518949 | — |
| 생성물 | HCID 178526847 | HCID 178526847 | 25.8% |
반응 단계
The title compound was prepared in a manner similar to that described in Example 5 starting with 2-(trifluoromethyl) phenyl isothiocyanate. The intermediate 4-[2-(trifluoromethyl)phenyl]-3-thiosemicarbazide (2.04 g) was treated with ethyl chloroformate (1.09 g) as in example 5. The reaction product 3-hydroxy-5-mercapto-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole (0.78 g) was reacted with 0.63 g of 2-bromo-5-nitrothiazole as in Example 5. Crystallization from ethanol and water gave 0.3 g of 3-hydroxy-5-[(5-nitrothiazol-2-yl)mercapto]-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole, a yellow solid, MP 183-185° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06080772 |
| 출처 데이터셋 | uspto-grants-2000_06 |
| ORD ID | ord-34274b4e4709431983296092f192cfbe |
| 출처 메모 | uspto-grants-2000_06 |