Triethylamine → N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-N-(2-pyridylmethyl)-glycine ethyl ester

HRID 1422237노트

반응식

HRID 1422237 반응식
Br[CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.[CH2:20]([O:22][C:23](=[O:33])[CH2:24][NH:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1)[CH3:21].C(N(CC)CC)C>C(#N)C>[CH2:20]([O:22][C:23](=[O:33])[CH2:24][N:25]([CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2)[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1)[CH3:21]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 13236080Ethyl N-((pyridin-2-yl)methyl)glycinateHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

생성물 1

HCID 18706566N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-N-(2-pyridylmethyl)-glycine ethyl ester

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

150 ml (0.46 mmol) of 5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline, 98 mg (1.1 equiv.) of N-(2-pyridylmethyl)-glycine ethyl ester and 0.076 ml (1.2 equiv.) of triethylamine are stirred at reflux in 5 ml of acetonitrile for 20 hours. The mixture is concentrated by evaporation and the residue is suspended in diethyl ether and filtered. After drying, the title compound is obtained in the form of a white powder.

후처리

  1. concentrationThe mixture is concentrated by evaporation
  2. filtrationfiltered
  3. customAfter drying

출처 및 근거

ORD 기록
ord-faf802640b7d47749a89fe04a61bba38
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080743

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