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Triethylamine → N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-valeric acid amide

HRID 1422244
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HRID 1422244 반응식
C(N(CC)CC)C.[CH3:8][CH2:9][CH2:10][CH2:11][C:12](Cl)=[O:13].[NH2:15][CH2:16][C:17]1[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[CH:24]=[C:23]2[C:18]=1[N:19]=[C:20]([O:32][CH3:33])[C:21]([O:30][CH3:31])=[N:22]2>COC(C)(C)C.ClCCl>[CH3:31][O:30][C:21]1[C:20]([O:32][CH3:33])=[N:19][C:18]2[C:23](=[CH:24][C:25]([N+:27]([O-:29])=[O:28])=[CH:26][C:17]=2[CH2:16][NH:15][C:12](=[O:13])[CH2:11][CH2:10][CH2:9][CH3:8])[N:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 179152965-Aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline

생성물 1

HCID 54181386N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-valeric acid amide

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 15413
tert-Butyl methyl ether
용매

실험 절차

79 μl (0.567 mmol) of triethylamine and 55 μl (0.454 mmol) of n-valeroyl chloride are added to a suspension of 100 mg (0.378 mmol) of 5-aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline in 2 ml of tert-butyl methyl ether and the mixture is stirred at room temperature for 16 hours. The mixture is then taken up in dichloromethane, washed with 1 N hydrochloric acid and with 1 N sodium hydroxide solution, dried over sodium sulfate and concentrated by evaporation. The title compound is obtained in the form of a yellowish powder.

후처리

  1. washwashed with 1 N hydrochloric acid and with 1 N sodium hydroxide solution
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-affe4107c7964e84a88b14953e47736f
출처 데이터셋
uspto-grants-2000_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06080743

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