Hydrogen Peroxide → HCID 10867638, 화합물

HRID 1422317노트

반응식

HRID 1422317 반응식
[CH2:1]([O:8][C:9]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:10]=1C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)[OH:19].OO>CO>[CH2:1]([O:8][C:9]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:10]=1[OH:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 110641372-benzyloxy-3-methylbenzaldehyde

생성물 1

HCID 10867638HCID 10867638, 화합물수율 70%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Benzyloxy-3-methylbenzaldehyde prepared by the above 2-(1) 20.0 g (88.4 mmol) was dissolved in methanol 100 ml and thereto was added sulfuric acid 20.0 g (203 mmol) and then added 30% hydrogen peroxide 30.1 g (265 mmol). The mixture was refluxed for 2 hours. After disappearance of the raw material, the solution was concentrated in vacuo, neutralized with a saturated sodium bicarbonate solution and extracted with methylene chloride. The solvent was removed in vacuo and the residue was purified by silica gel chromatography (n-hexane-ethyl acetate) to give 2-benzyloxy-3-methylphenol 13.3 g (yield: 70%).

후처리

  1. temperatureThe mixture was refluxed for 2 hours
  2. concentrationAfter disappearance of the raw material, the solution was concentrated in vacuo
  3. extractionextracted with methylene chloride
  4. customThe solvent was removed in vacuo
  5. customthe residue was purified by silica gel chromatography (n-hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-6a2446198f034f78870c6c4abbe55acc
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080895

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