Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 3-Amino-1,2-propanediol | HCID 73561 | — |
| 반응물 | n-hydroxysulfosuccinimide sodium salt | HCID 3520574 | — |
| 반응물 | 2-[4,7-Bis(1,4-dicarboxybutyl]-1,4,7,10-tetraazacyclododec-1-yl]hexanoic acid | HCID 66739089 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane | HCID 107830 | — |
반응 단계
A solution containing 0.26 mg of 3-aminopropane-1,2-diol in 6 μl of water is prepared. The pH is adjusted to 6 with HCl. 0.5 mg of gallium complex of 2-[4,7-bis(1,4-dicarboxybutyl]-1,4,7,10-tetraazacyclododec-1-yl]hexanoic acid are added to the above solution. The pH is again adjusted before adding 0.071 mg of sulfo-NHS and 0.062 mg of EDCI. The pH is checked and adjusted to 6 with 2N NaOH. After an overnight period at AT, the reaction medium is concentrated to approximately 2 ml and then precipitated from 10 ml of ethanol. The solid is filtered off, washed with ethanol and diethyl ether, and then purified on silanized silica RP2, elution being carried out with water only. 0.2 mg of product is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08926945B2 |
| 출처 데이터셋 | uspto-grants-2015_01 |
| ORD ID | ord-367de10a3cab4b43a995523b367e5bc6 |
| 출처 메모 | uspto-grants-2015_01 |