Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butyl iodide → butyl 1-butyl-1H-indole-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butyl iodide | HCID 10962 | — |
| 반응물 | 1-butyl-1H-indole-6-carboxylic acid | HCID 21085167 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | butyl 1-butyl-1H-indole-6-carboxylate | HCID 21086016 | — |
반응 단계
1-Butyl-1H-indole-6-carboxylic acid (0.450 g) was dissolved in dimethyl sulfoxide (10 mL). Potassium tert-butoxide (0.317 g) was added and the mixture was stirred for 10 min at room temperature. Iodobutane (0.33 mL) was added and the mixture was allowed to stir at room temperature for 6 h. Water was then added and the mixture was partioned between ethyl acetate, water, and brine, and dried over magnesium sulfate, filtered, and concentrated. Silica gel chromatography using heptane/dichloromethane (30/70) gave butyl 1-butyl-1H-indole-6-carboxylate (0.429 g). MS (ESI+) for C17H23NO2+H1 m/z 274.20 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727997B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-32acb31f6e0644ba9d336afcf69903fe |
| 출처 메모 | uspto-grants-2010_06 |