Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-O-benzyl-3,6-di-O-acetyl-D-glucose
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | [(2R,3S,4R)-4-acetyloxy-3-phenylmethoxy-3,4-dihydro-2H-pyran-2-yl]methyl acetate | HCID 2734732 | — |
| 반응물 | Hydrobromide monohydrate | HCID 22326455 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-O-benzyl-3,6-di-O-acetyl-D-glucose | HCID 86654839 | — |
반응 단계
48% Hydrobromic acid water solution (0.5 mL) was added to a mixture of 4-O-benzyl-3,6-di-O-acetyl-D-glucal (5 mmol) in tetrahydrofuran (50 mL), and obtained solution was stirred in room temperature. After reaction was completed (TLC) the reaction mixture was poured into the 10% water solution of sodium bicarbonate (125 mL), and water solution was extracted with ethyl acetate (3×30 mL). Combined organic extracts were washed with water and dried over sodium sulfate. Drying agent and solvents were removed and product was purified by column chromatography (SilicaGel 60 Merck), using hexanes:ethyl acetate as eluents.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08927506B2 |
| 출처 데이터셋 | uspto-grants-2015_01 |
| ORD ID | ord-263635c797c5441f9a11b6f5bc0ab991 |
| 출처 메모 | uspto-grants-2015_01 |