6-Bromo-1-methylquinolin-2(1H)-one → 3-(2-Methyl-4-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)but-3-yn-2-yl)-6-(2-methylallyl)-6-phenyl-1,3-oxazinan-2-one

HRID 1422648노트

반응식

HRID 1422648 반응식
O[C:2]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([CH2:15][C:16]([CH3:18])=[CH2:17])[CH2:3][CH2:4][N:5]([C:10]([CH3:14])([C:12]#[CH:13])[CH3:11])[C:6](=[O:9])[O:7]C.Br[C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[N:32]([CH3:36])[C:31](=[O:37])[CH:30]=[CH:29]2>>[CH3:14][C:10]([N:5]1[CH2:4][CH2:3][C:2]([CH2:15][C:16]([CH3:18])=[CH2:17])([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:7][C:6]1=[O:9])([C:12]#[C:13][C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[N:32]([CH3:36])[C:31](=[O:37])[CH:30]=[CH:29]2)[CH3:11]

참가 물질

3

반응물 2

HCID 218161626-Bromo-1-methylquinolin-2(1H)-oneHCID 86669141Methyl 3-hydroxy-5-methyl-3-phenylhex-5-enyl(2-methylbut-3-yn-2-yl)carbamate

생성물 1

HCID 509057363-(2-Methyl-4-(1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)but-3-yn-2-yl)-6-(2-methylallyl)-6-phenyl-1,3-oxazinan-2-one

실험 절차

The title compound was prepared from methyl 3-hydroxy-5-methyl-3-phenylhex-5-enyl(2-methylbut-3-yn-2-yl)carbamate and 6-bromo-1-methylquinolin-2(1H)-one following procedures analogous to those described in Example 1 Steps 3 and 4. LC-MS Method 1 tR=1.92 min, m/z=455; 1H NMR (CDCl3) 1.64 (s, 3H), 1.69 (s, 3H), 1.82 (s, 6H), 2.26 (m, 1H), 2.40 (m, 1H), 2.61 (AB quartet, 2H), 3.08 (m, 1H), 3.64 (m, 1H), 3.71 (s, 3H), 4.64 (s, 1H), 4.83 (s, 1H), 6.77 (d, 1H), 7.25-7.65 (9H).

출처 및 근거

ORD 기록
ord-2a23f0d305ec442d84f7d67968bd71ec
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927539B2

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