4-Oxothiolane-3-carbonitrile → HCID 66980303, 화합물

HRID 1423312노트

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HRID 1423312 반응식
O=[C:2]1[CH2:6][S:5][CH2:4][CH:3]1[C:7]#[N:8].[C:9]1([C:15]2[N:20]=[CH:19][C:18]([C:21]3[CH:22]=[N:23][NH:24][C:25]=3[NH2:26])=[CH:17][CH:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[C:9]1([C:15]2[N:20]=[CH:19][C:18]([C:21]3[CH:22]=[N:23][N:24]4[C:7]([NH2:8])=[C:3]5[CH2:4][S:5][CH2:6][C:2]5=[N:26][C:25]=34)=[CH:17][CH:16]=2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 3266764-Oxothiolane-3-carbonitrileHCID 66980248HCID 66980248, 화합물

생성물 1

HCID 66980303HCID 66980303, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
115 °C

실험 절차

A mixture of 4-oxotetrahydrothiophene-3-carbonitrile (77.6 mg, 0.61 mmol) and 4-(6-phenylpyridin-3-yl)-1H-pyrazol-5-amine (144 mg, 0.61 mmol) in toluene (10 mL) was heated at 115° C. overnight. Concentration and purification with prep-LC provided 3-(6-phenylpyridin-3-yl)-5,7-dihydropyrazolo[1,5-a]thieno[3,4-d]pyrimidin-8-amine: LCMS tR=1.48 Min (5 min run, UV254mn), Mass calculated for, M+345.1, observed LC/MS m/z 346.1 (M+H).

후처리

  1. concentrationConcentration and purification

출처 및 근거

ORD 기록
ord-007ae8e298f2460e8c78d3fd04f0b6b0
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927562B2

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