Danegaptide Hydrochloride → (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate

HRID 1423862노트

반응식

HRID 1423862 반응식
[ClH:1].[NH2:2][CH2:3][C:4]([N:6]1[CH2:10][C@H:9]([NH:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][C@H:7]1[C:20]([OH:22])=[O:21])=[O:5]>C(O)(C)C.O>[OH2:5].[ClH:1].[NH2:2][CH2:3][C:4]([N:6]1[CH2:10][C@H:9]([NH:11][C:12](=[O:19])[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:8][C@H:7]1[C:20]([OH:22])=[O:21])=[O:5]

참가 물질

3

반응물 1

HCID 44563896Danegaptide Hydrochloride

생성물 1

HCID 68515358(2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate

시약·촉매·용매 1

HCID 21889133Propan-2-ol--water (1/1)용매

실험 절차

32 mg of amorphous (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride was dissolved in three volumes of an isopropanol/water (19.5:0.5 ratio by volume) mixed solvent at room temperature. The container was left open, and the crystals that had formed were collected. The crystalline solid was dried at 40-50° C. under vacuum to give crystalline (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate.

후처리

  1. additionmixed solvent at room temperature
  2. waitThe container was left open
  3. customthe crystals that had formed
  4. customwere collected
  5. customThe crystalline solid was dried at 40-50° C. under vacuum

출처 및 근거

ORD 기록
ord-86beba2fb8d846608b7d17aec534caa4
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927590B2

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