Isobutylene oxide → N-Cyclopropyl-3-fluoro-N-[1-(2-hydroxy-2-methyl-propyl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
반응식
[CH:1]1([N:4]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:5](=[O:18])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[C:8]([F:17])[CH:7]=2)[CH2:3][CH2:2]1.[CH3:25][C:26]1([CH3:29])[O:28][CH2:27]1>>[CH:1]1([N:4]([CH:19]2[CH2:24][CH2:23][N:22]([CH2:25][C:26]([OH:28])([CH3:29])[CH3:27])[CH2:21][CH2:20]2)[C:5](=[O:18])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[C:8]([F:17])[CH:7]=2)[CH2:2][CH2:3]1참가 물질
3
실험 절차
The title compound is prepared from N-cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 1,1-dimethyloxirane following a procedure analogous to that described for Intermediate 2. LC (method 2): tR=0.98 min; Mass spectrum (ESI+): m/z=402 [M+H]+.
출처 및 근거
- ORD 기록
- ord-d3c887bd559f4a008e1529814455abda
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08927726B2
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