Diethyl Ether → Methyl 3-butanoyl-4-hydroxybenzoate

HRID 14248노트

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HRID 14248 반응식
[C:1]([CH:6]1[CH2:11][C:10](O)([C:12]([O:14][CH3:15])=[O:13])[CH:9]=[CH:8][C:7]1=[O:17])(=[O:5])[CH2:2][CH2:3][CH3:4].B(F)(F)F.O(CC)CC>C1C=CC=CC=1>[C:1]([C:6]1[CH:11]=[C:10]([CH:9]=[CH:8][C:7]=1[OH:17])[C:12]([O:14][CH3:15])=[O:13])(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6356Boron trifluorideHCID 21086214HCID 21086214, 화합물

생성물 1

HCID 12533653Methyl 3-butanoyl-4-hydroxybenzoate

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a stirred solution of methyl 5-butyryl-1-hydroxy-4-oxocyclohex-2-ene-1-carboxylate in benzene was added BF3.O(Et)2 (1.3 mL, 10 mmol). The mixture was stirred for 0.25 h and then quenched with saturated sodium bicarbonate followed by extraction with dichloromethane. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to afford methyl 3-butyryl-4-hydroxybenzoate which was used without further purification or characterization.

후처리

  1. customquenched with saturated sodium bicarbonate
  2. extractionfollowed by extraction with dichloromethane
  3. dry with materialThe organic layer was dried (sodium sulfate)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d45898382cf545c6a8d183ff834260e4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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