Thionyl Chloride → 4-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

반응식

[Cl:1][C:2]1[N:3]=[C:4]([C:9]([OH:11])=O)[NH:5][C:6]=1[CH2:7][CH3:8].S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]([Cl:14])=[O:11])[NH:5][C:6]=1[CH2:7][CH3:8]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 675489294-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

생성물 1

HCID 866485554-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

반응 조건

온도: 75 °C

실험 절차

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (1d) (55 mg, 0.29 mmol) was dissolved in thionyl chloride (1.5 mL), and the mixture was stirred at 75° C. for 50 minutes. The reaction solution was concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

후처리

concentrationThe reaction solution was concentrated under reduced pressure
customThe resulting compound was used for the next reaction without purification

출처 및 근거

ORD 기록: ord-dd3f067052344a3f8f5b6f674aa55008
출처 데이터셋: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08927588B2

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