Methyl 2-(4-{[(benzyloxy)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate → Methyl 2-(4-amino-3-methylphenyl)-1,3-oxazole-4-carboxylate

HRID 1425110노트

반응식

HRID 1425110 반응식
C(OC([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:19][CH:20]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[N:22]=2)=[CH:14][C:13]=1[CH3:27])=O)C1C=CC=CC=1>[Pd].CO>[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[O:19][CH:20]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[N:22]=2)=[CH:14][C:13]=1[CH3:27]

참가 물질

4

반응물 1

HCID 68405856Methyl 2-(4-{[(benzyloxy)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate

생성물 1

HCID 67548797Methyl 2-(4-amino-3-methylphenyl)-1,3-oxazole-4-carboxylate수율 102.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The same operation as in Example (95b) was performed using methyl 2-(4-{[(benzyloxy)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate obtained in Example (109d) (0.4 g, 1.09 mmol), 10% Pd/C (0.2 g) and methanol (10 mL), to obtain 0.26 g of the title compound as a colorless oily substance (100%).

출처 및 근거

ORD 기록
ord-b1ded0aaa91f4d0fb9de8accc19c7cba
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927588B2

반응 노트

불러오는 중…