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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1425205생성일: 2026년 10월 26일

Phenylglyoxylic Acid → cis(+/-)-4-Chloro-N-{3-ethoxy-1-[oxo(phenyl)acetyl]piperidin-4-yl}-5-ethyl-1H-imidazole-2-carboxamide

https://huagongshe.com/reaction/1425205

반응식

참여 물질

역할이름HCID투입량
반응물Phenylglyoxylic AcidHCID 11915—
반응물cis(+/-)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochlorideHCID 86648665—
용매DimethylformamideHCID 6228—
생성물cis(+/-)-4-Chloro-N-{3-ethoxy-1-[oxo(phenyl)acetyl]piperidin-4-yl}-5-ethyl-1H-imidazole-2-carboxamideHCID 8664867967%

반응 단계

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol) and benzoylformic acid (45 mg, 0.30 mmol) were suspended in DMF (3 mL). The suspension was subjected to the same operation as in Example (138a) to obtain 86.2 mg of the title compound as a colorless amorphous solid (67%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08927588B2
출처 데이터셋uspto-grants-2015_01
ORD IDord-3670f20867ff43b8b89ec5697516e7aa
출처 메모uspto-grants-2015_01