Methyl cis(+/-)-6-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyrimidine-4-carboxylate → HCID 86648728, 화합물

HRID 1425248노트

반응식

HRID 1425248 반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[CH:22][N:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:19]=2)[CH2:14][C@H:13]1[O:28][CH3:29])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[CH:22][N:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:19]=2)[CH2:14][C@H:13]1[O:28][CH3:29]

참가 물질

3

반응물 1

HCID 86648725Methyl cis(+/-)-6-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyrimidine-4-carboxylate

생성물 1

HCID 86648728HCID 86648728, 화합물수율 71.8%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

The same operation as in Example (160c) was performed using methyl cis(±)-6-(4-{[benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyrimidine-4-carboxylate obtained in Example (174c) (111 mg, 0.28 mmol) and a 10% palladium-carbon catalyst (130 mg), to obtain 53.5 mg of the title compound as a pale yellow oily substance. The resulting compound was used for the next reaction without purification.

출처 및 근거

ORD 기록
ord-99031b79c51d42c3a33bee441ee15f52
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927588B2

반응 노트

불러오는 중…